I've noticed there is currently a major bug with the new update. After the first trigger pull in vats weapons stop dealing damage all together until you exit VATS (In some cases its refused to re-enter VATS for me).
This means if don't completely kill the enemy in the first burst of fire you have to exit VATS, if you cant kill it in a single clip you have to exit VATS, if you are using a singe shot weapon you have to exit VATS every single shot. This will make any sort of VATS based build completely unplayable.
I've tested this with legendary and non-legendary weapons, Pistols, Rifles, and Shotguns are all affected for sure. I haven't had a chance to test this with melee.
/u/Ladydevann and /u/Valseek Please pass this along ASAP. I'm guessing it was an attempt to ninja-nerf the unlimited AP builds as those no longer seem to work, but it has completely broken VATS, at least for ranged weapons.
Here is a clip showing my first shot doing damage followed by other shots registering hits and damage but not actually dealing any. Then a second full mag dump dealing damage, followed by the mag after the reload doing no damage. https://www.youtube.com/watch?v=OAwh-KWbN9A&feature=youtu.be
Edit: The bug seems very hit and miss like the old Legendary Damage Bug, after logging in and out several times it is working normally again for the moment.