5-x
A new rune is a lot of checklists, I hope the team finds the time (lol) to tick all necessary boxes such as
- time talisman, tiara, and staff
- feed it to wicked hood
- new altar, maybe miniquest to locate it?
- put time runes in pouches
- add time rune to ZMI
- check new spells with greater runic staff
- V's boost and moonstone ring effect on crafting time runes
- rune shops?
- vis wax ingredient?
and so on and so forth.
It would also be a great idea to bring back miasmic spells such as miasmic barrage - they slow your opponent down, it's a great thematic fit!
Important to mention that all endeavours with 110s have a principle that the player, you, are the "pioneer" of these new resources. You might be the only one, or one of very few, who knows how to put your skills to use and find, harvest, harness these 100+ resources
As such, not everything is exactly a "plug-in" point and that could be down to that principle or a bit of narrative, and or allowing the design space to do interesting things without necessarily being tethered to all existing content and mechanics as a checklist.
For example, if you are currently the only person or one of few who knows/finds out about Time Runes, it wouldn't make sense for them to just appear in shops