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(2020) Can I load mods into old saves?

This thread was added on January 27, 2020, with posts from Klonan.

Original Post

I have a base with 100+ hours into it and I discovered some mods (Aircraft and MIRV) that I want to play with, but I noticed that even after toggling on the mods, they don't seem to exist in the game.

Is there a trick or do I need to start a new game?

Remake12

It does not from the description.

https://mods.factorio.com/mod/MIRV

There is a technology to unlock the MIRV item